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KMID : 1001020180160010001
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Journal of Urologic Oncology
2018 Volume.16 No. 1 p.1 ~ p.6
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The Role of MicroRNAs in Oncogenesis and Progression of Prostate Cancer
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Kim Won-Tae
Yun Seok-Joong
Kim Wun-Jae
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Abstract
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MicroRNAs (miRNAs) are small noncoding RNAs that target mRNA to reduce gene and protein expression by repressing their targets’ translation or inducing mRNA degradation. They play fundamental roles in various cancers, including prostate cancer. Each single miRNA may regulate hundreds of genes, and a certain gene may serve as a target by multiple miRNAs. Hence, miRNAs modulate, cell cycle, apoptosis, epithelial-mesenchymal transition (EMT), and metastasis, etc. In this review, we will summarize the several miRNAs that may function as oncogenes and tumor suppressors. And we will describe the each miRNAs associated with cell cycle, apoptosis, EMT, and metastasis in prostate cancer.
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KEYWORD
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Prostatic neoplasms, MicroRNAs, Carcinogenesis
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